Minimal change disease is the most common cause of nephrotic syndrome in children. It is also seen in adults with nephrotic syndrome, but is less common. Those with mcd experience the signs and symptoms of nephrotic syndrome much quicker than they would with other glomerular diseases.
Management of idiopathic nephrotic syndrome in adults minimal change disease and focal segmental glomerulosclerosis. In evidence-based nephrology, molony da, craig jc (eds), wiley-blackwell, oxford 2009. Adult minimal-change disease clinical characteristics, treatment, and outcomes.
Minimal change disease (also known as mcd, minimal change glomerulopathy, and nil disease, among others) is a disease affecting the kidneys which causes a nephrotic syndrome. Nephrotic syndrome leads to the loss of significant amounts of protein in the urine, which causes the widespread oedema (soft tissue swelling) and impaired kidney function commonly experienced by those affected by the disease. It is most common in children and has a peak incidenceat 2 to 6 years of age.
В minimal change disease is a kidney disease in which there is damage to the filtering units of the kidney (glomeruli). It is the most common cause of nephrotic syndrome in children. 1 2 nephrotic syndrome is comprised of a group of symptoms including protein in the urine ( proteinuria ), low protein levels in the blood, high cholesterol and triglycerides, an increased risk for blood clots.
В minimal change disease is responsible for idiopathic nephrotic syndrome in 75 of children and up to 30 of adults (1152).